Chromasol SCX column has media with uniquechemistry of non aromaticsulfonic acid phase in addition to the functional polar group in the same phasebound to porous silica for use in normal phase mode. This column is employed for the purification strong organic acid molecules (pH =2-8) and comes of use in acid-free RP or HILIC mode havingstrong selectivity for positively charged molecules. This column has application design versatile for the separation of nucleic acids, amino acids, polyamines, drugs and other cationic species with different pH.